产品
编 号:F614146
分子式:C27H21BrClNO4S
分子量:570.88
产品类型
结构图
CAS No: 244101-03-9
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生物活性:
L-826266 is a selective and competitive EP3 receptor antagonist. L-826266 can be used for convulsive disorders research.
体内研究:
L-826266 (0.01-1 nmol/site; i.c.v.; once) delays seizures, and increases the latency for clonic and generalized tonic-clonic seizures induced by PTZ.Animal Model:Adult male Wistar rats (250-300 g) injected with Pentylenetetrazol (PTZ)
Dosage:0.01 nmol/site, 0.1 nmol/site or 1 nmol/site
Administration:i.c.v.; once
Result:Increased the latency for clonic and generalized tonic-clonic seizures induced by PTZ.
体外研究:
In adult rat hippocampal slices, L-826266 (1 μM) prevents the PGE2-induced decrease of Na+,K+-ATPase activity.