产品
编 号：F613757
分子式：C11H11NO2
分子量：189.21
分子式：C11H11NO2
分子量：189.21
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
询价
询价
结构图
CAS No: 278605-15-5
产品详情
生物活性：
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
p-Ethynylphenylalanine (30 mg/kg；腹腔注射) 降低大鼠中脑而非组织中的 5-HT 和 5-HIAA 水平。 p-Ethynylphenylalanine 不抑制芳香族氨基酸脱羧酶。Animal Model:Male Sprague-Dawley rats (200 g)
Dosage:30 mg/kg
Administration:Intraperitoneal injection
Result:Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
体外研究：
p-Ethynylphenylalanine 选择性可逆地抑制5-羟色胺的生物合成。 p-Ethynylphenylalanine 对多种重组5-HT受体 (5-HT1，5-HT2，5-HT4，5-HT5，5-HT6，和 5-HT7)。
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
p-Ethynylphenylalanine (30 mg/kg；腹腔注射) 降低大鼠中脑而非组织中的 5-HT 和 5-HIAA 水平。 p-Ethynylphenylalanine 不抑制芳香族氨基酸脱羧酶。Animal Model:Male Sprague-Dawley rats (200 g)
Dosage:30 mg/kg
Administration:Intraperitoneal injection
Result:Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
体外研究：
p-Ethynylphenylalanine 选择性可逆地抑制5-羟色胺的生物合成。 p-Ethynylphenylalanine 对多种重组5-HT受体 (5-HT1，5-HT2，5-HT4，5-HT5，5-HT6，和 5-HT7)。
产品资料
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