产品
编 号：F613606
分子式：C26H35NO5
分子量：441.56
分子式：C26H35NO5
分子量：441.56
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 299420-83-0
产品详情
生物活性：
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
体内研究：
UC-514321 (2.5 mg/kg，ip，每天一次，持续 10 天) 在 AML 小鼠模型中表现出比 NSC370284 更强的抗肿瘤活性。Animal Model:MLL-AF9-AML mice and AE9a-AML model.
Dosage:2.5 mg/kg.
Administration:IP., once per day, for 10 days.
Result:Showed an improved therapeutic effect in AML mouse models in vivo. Prolonged the median survival over three fold.
体外研究：
UC-514321 增加 AML 细胞的凋亡，而不是正常 HSPC。 UC-514321 (0-500 nM，48 小时) TET1 信号 依赖性地抑制 AML 细胞活力 。
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
体内研究：
UC-514321 (2.5 mg/kg，ip，每天一次，持续 10 天) 在 AML 小鼠模型中表现出比 NSC370284 更强的抗肿瘤活性。Animal Model:MLL-AF9-AML mice and AE9a-AML model.
Dosage:2.5 mg/kg.
Administration:IP., once per day, for 10 days.
Result:Showed an improved therapeutic effect in AML mouse models in vivo. Prolonged the median survival over three fold.
体外研究：
UC-514321 增加 AML 细胞的凋亡，而不是正常 HSPC。 UC-514321 (0-500 nM，48 小时) TET1 信号 依赖性地抑制 AML 细胞活力 。
产品资料
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