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编 号：F613474
分子式：C24H24N2O7
分子量：452.46
分子式：C24H24N2O7
分子量：452.46
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CAS No: 308246-52-8
产品详情
生物活性：
LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
体内研究：
LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.Animal Model:Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts.
Dosage:10, 25, or 50 mg/kg/week, 4 weeks
Administration:I.V. push via tail vein
Result:Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.
体外研究：
The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM.LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.
LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
体内研究：
LMP744 (MJ-III65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.Animal Model:Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts.
Dosage:10, 25, or 50 mg/kg/week, 4 weeks
Administration:I.V. push via tail vein
Result:Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.
体外研究：
The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM.LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.
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