产品
编 号：F613270
分子式：C18H24BrNO
分子量：350.29
分子式：C18H24BrNO
分子量：350.29
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
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询价
100mg
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询价
结构图
CAS No: 332108-65-3
产品详情
生物活性：
ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity.
体内研究：
ABMA (2 -200 mg/kg；腹膜内注射；雌性 BALB/c 小鼠) 处理可保护小鼠免受经鼻滴入 LD90 蓖麻毒素的影响。Animal Model:Pathogen-free female BALB/c mice (6 week-old) with ricin
Dosage:2 mg/kg, 20 mg/kg, 200 mg/kg
Administration:Intraperitoneal injection
Result:A statistically significant protection according to survival curves was observed with a single ip dose of 2?mg/kg. The 20?mg/kg dose fully protected animals through to day 21. The 200?mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.
体外研究：
ABMA protects cells against four bacterial toxins (Corynebacterium diphtheriae (DT; EC50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC50 of 73.3?μM),? Clostridium sordellii lethal toxin (TcsL; EC50 of 86.7 μM)), three viruses (Ebola (EC50 of 3.3?μM), rabies (EC50 of 19.4?μM), dengue-4 virus ( EC50 of 8.2?μM)), two species of Chlamydiales intracellular bacteria (Simkania negevensis and Chlamydia trachomatis), and the parasite Leishmania infantum (EC50 of 7.1?μM) at micromolar level.?In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC50 of 3.8?μM, and a protection factor (R) at 30?μM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days.
ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity.
体内研究：
ABMA (2 -200 mg/kg；腹膜内注射；雌性 BALB/c 小鼠) 处理可保护小鼠免受经鼻滴入 LD90 蓖麻毒素的影响。Animal Model:Pathogen-free female BALB/c mice (6 week-old) with ricin
Dosage:2 mg/kg, 20 mg/kg, 200 mg/kg
Administration:Intraperitoneal injection
Result:A statistically significant protection according to survival curves was observed with a single ip dose of 2?mg/kg. The 20?mg/kg dose fully protected animals through to day 21. The 200?mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.
体外研究：
ABMA protects cells against four bacterial toxins (Corynebacterium diphtheriae (DT; EC50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC50 of 73.3?μM),? Clostridium sordellii lethal toxin (TcsL; EC50 of 86.7 μM)), three viruses (Ebola (EC50 of 3.3?μM), rabies (EC50 of 19.4?μM), dengue-4 virus ( EC50 of 8.2?μM)), two species of Chlamydiales intracellular bacteria (Simkania negevensis and Chlamydia trachomatis), and the parasite Leishmania infantum (EC50 of 7.1?μM) at micromolar level.?In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC50 of 3.8?μM, and a protection factor (R) at 30?μM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days.
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