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编 号:F065080
分子式:C22H27ClN4O5
分子量:462.93
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.

体内研究:
Dorzagliatin (低剂量 10 mg/kg,高剂量 30 mg/kg;胃内给药;每天上午 8:00,持续一个月) 对糖尿病大鼠的血糖水平产生降糖作用[2。Animal Model:Male Sprague-Dawley (SD) rats (aged approximately 6–8 weeks and weighing 200-230?g)[2
Dosage:Low-dose (10?mg/kg), and high-dose (30?mg/kg)
Administration:Administered intragastrically (i.g.); daily (8:00 AM) for one month
Result:Exerted a glucose-lowering effect on the glucose levels.
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