产品
编 号：F613189
分子式：C10H3ClF3NO4
分子量：293.58
分子式：C10H3ClF3NO4
分子量：293.58
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CAS No: 342795-11-3
产品详情
生物活性：
Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research.
体内研究：
Namoline (0.02 mg;ip; daily) severely blunts xenograft tumor growth in nude mice with LNCaP cells.
体外研究：
Namoline (50 μM; 24, 48, 72 hours) reduces androgen-induced proliferation of LNCaP cells.Namoline (50 μM) specifically impairs AR agonist R1881-induced (1 nM) demethylation of H3K9me1 and H3K9me2 in LNCaP cells. Namoline (50 μM) does not affect the enzymatic activities of MAOs under these conditions.
Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research.
体内研究：
Namoline (0.02 mg;ip; daily) severely blunts xenograft tumor growth in nude mice with LNCaP cells.
体外研究：
Namoline (50 μM; 24, 48, 72 hours) reduces androgen-induced proliferation of LNCaP cells.Namoline (50 μM) specifically impairs AR agonist R1881-induced (1 nM) demethylation of H3K9me1 and H3K9me2 in LNCaP cells. Namoline (50 μM) does not affect the enzymatic activities of MAOs under these conditions.
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