产品
编 号：F612969
分子式：C24H31Cl3FN3O3
分子量：534.88
分子式：C24H31Cl3FN3O3
分子量：534.88
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 380449-54-7
产品详情
生物活性：
Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells.
体内研究：
Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg；静脉注射；每周两次，持续两周) 在异种移植小鼠模型中显示出抗 MM 活性。Animal Model:CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model)
Dosage:3 mg/kg
Administration:1.v.; twice-weekly for two weeks
Result:Significantly inhibited MM tumor growth and prolonged survival of mice.
体外研究：
Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM；24 小时) 降低 MM.1S、INA-6、RPMI-8226、MM.1R、Dox-40、ARP-1 和 ANBL-6 细胞的活力，具有浓度依赖性。 Melflufen hydrochloride 诱导 MM.1S 细胞凋亡。 Melflufen hydrochloride 也是一种有效的外泌体分泌激活剂。
Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells.
体内研究：
Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg；静脉注射；每周两次，持续两周) 在异种移植小鼠模型中显示出抗 MM 活性。Animal Model:CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model)
Dosage:3 mg/kg
Administration:1.v.; twice-weekly for two weeks
Result:Significantly inhibited MM tumor growth and prolonged survival of mice.
体外研究：
Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM；24 小时) 降低 MM.1S、INA-6、RPMI-8226、MM.1R、Dox-40、ARP-1 和 ANBL-6 细胞的活力，具有浓度依赖性。 Melflufen hydrochloride 诱导 MM.1S 细胞凋亡。 Melflufen hydrochloride 也是一种有效的外泌体分泌激活剂。
产品资料
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