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编 号：F612796
分子式：C28H34O5
分子量：450.57
分子式：C28H34O5
分子量：450.57
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CAS No: 419532-92-6
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生物活性：
Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM.
体外研究：
Phenylpyropene C (0.1-1000 μM) inhibits ACAT activity with the IC50 of 16.0 μM in a dose dependent fashion.Phenylpyropene C inhibits the IFN-γ mediated expression of the reporter gene with IC50s of 5.4 μM to approximately 10.8 μM.Phenylpyropene C inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 10.8 μM in LPS/IFN-γ stimulated J774 mouse macrophages.Phenylpyropene C inhibits the activation of the p38 MAP kinase, which is involved in the inducible expression of many proinflammatory genes.
Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM.
体外研究：
Phenylpyropene C (0.1-1000 μM) inhibits ACAT activity with the IC50 of 16.0 μM in a dose dependent fashion.Phenylpyropene C inhibits the IFN-γ mediated expression of the reporter gene with IC50s of 5.4 μM to approximately 10.8 μM.Phenylpyropene C inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 10.8 μM in LPS/IFN-γ stimulated J774 mouse macrophages.Phenylpyropene C inhibits the activation of the p38 MAP kinase, which is involved in the inducible expression of many proinflammatory genes.
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