产品
编 号：F612788
分子式：C28H30FNO5
分子量：479.54
分子式：C28H30FNO5
分子量：479.54
产品类型
规格
价格
是否有货
结构图
CAS No: 421571-66-6
产品详情
生物活性：
SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with?P. yoelii.
体内研究：
SJ000025081 (intraperitoneal injection; 25 mg/kg; single dose; suspension in 1% methylcellulose) exhibits a good PK profile, the Cmax, Cmax/Dose, Tmax and AUC values are 0.224 μg/ml, 0.0113 μg/ml per mg/ml, 1.0 h and 0.224 μg.h/ml, respectively.SJ000025081 (intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days) exhibits an antimalarial activity in a dose-dependent manner and displays efficacy in a murine malaria model infected with?P. yoelii.?SJ000025081 can result in a 90% suppression of the parasitemia.Animal Model:6 weeks old CD-1 mice
Dosage:5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration:Intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days
Result:Was active in a malaria murine model infected with P. yoelii.
SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with?P. yoelii.
体内研究：
SJ000025081 (intraperitoneal injection; 25 mg/kg; single dose; suspension in 1% methylcellulose) exhibits a good PK profile, the Cmax, Cmax/Dose, Tmax and AUC values are 0.224 μg/ml, 0.0113 μg/ml per mg/ml, 1.0 h and 0.224 μg.h/ml, respectively.SJ000025081 (intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days) exhibits an antimalarial activity in a dose-dependent manner and displays efficacy in a murine malaria model infected with?P. yoelii.?SJ000025081 can result in a 90% suppression of the parasitemia.Animal Model:6 weeks old CD-1 mice
Dosage:5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration:Intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days
Result:Was active in a malaria murine model infected with P. yoelii.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备