产品
编 号:F612290
分子式:C28H27N3O3
分子量:453.53
产品类型
结构图
CAS No: 521985-36-4
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产品详情
生物活性:
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2.
体外研究:
SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.