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编 号:F612290
分子式:C28H27N3O3
分子量:453.53
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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生物活性:
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2.

体外研究:
SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.
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