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编 号：F612277
分子式：C34H44F4N6O12
分子量：804.74
分子式：C34H44F4N6O12
分子量：804.74
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CAS No: 524746-03-0
产品详情
生物活性：
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma.
体内研究：
Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats.Animal Model:Male Wistar albino rats (250-350 g) with SCI
Dosage:0.8 μmol/kg
Administration:I.v. for 1 or 7 days
Result:Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury.
体外研究：
Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity.Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis.
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma.
体内研究：
Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats.Animal Model:Male Wistar albino rats (250-350 g) with SCI
Dosage:0.8 μmol/kg
Administration:I.v. for 1 or 7 days
Result:Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury.
体外研究：
Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity.Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis.
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