产品
编 号：F612236
分子式：C16H16ClNO3S
分子量：337.82
分子式：C16H16ClNO3S
分子量：337.82
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 544450-68-2
产品详情
生物活性：
COR659 is a potent and effective GABAB positive allosteric modulator (PAM). COR659 suppresses alcohol and chocolate self-administration in rats.
体内研究：
COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats.COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats.Animal Model:Male sP and Wistar rats.
Dosage:0, 2.5, 5 and 10 mg/kg.
Administration:Intraperitoneally (administered 30 min before the start of the self-administration, reinstatement, and locomotor activity sessions.).
Result:The magnitude of the reducing effect of the compound on number oflever-responses for alcohol averaged approximately 30, 55, and 70%, in comparison to the vehicle-treated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.The magnitude of the reducing effect of COR659 on number of lever-responses for alcohol averaged approximately 20, 40, and 80%, in comparison to the vehicletreated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.
体外研究：
COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
COR659 is a potent and effective GABAB positive allosteric modulator (PAM). COR659 suppresses alcohol and chocolate self-administration in rats.
体内研究：
COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats.COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats.Animal Model:Male sP and Wistar rats.
Dosage:0, 2.5, 5 and 10 mg/kg.
Administration:Intraperitoneally (administered 30 min before the start of the self-administration, reinstatement, and locomotor activity sessions.).
Result:The magnitude of the reducing effect of the compound on number oflever-responses for alcohol averaged approximately 30, 55, and 70%, in comparison to the vehicle-treated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.The magnitude of the reducing effect of COR659 on number of lever-responses for alcohol averaged approximately 20, 40, and 80%, in comparison to the vehicletreated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.
体外研究：
COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
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