产品
编 号：F611178
分子式：C68H122N16O19
分子量：1467.79
分子式：C68H122N16O19
分子量：1467.79
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CAS No: 800379-47-9
产品详情
生物活性：
KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair.
体内研究：
KLD-12 TFA (10-250 μg/rat，单剂量，骨折部位注射) 在股骨钻孔损伤的 Sprague-Dawley 大鼠模型中，剂量依赖地促进骨折部位的骨再生。Animal Model:Sprague-Dawley rats model with drill-hole injury in femur
Dosage:10-250 μg/rat
Administration:injection to the fracture site, single dose
Result:Increased osteoinduction and callus formation.
体外研究：
KLD-12 与 SDF-1 形成自组装多肽，提高骨髓基质细胞 (BMSC) 的存活率，通过 Wnt/β-catenin 通路促进 BMSC 成骨分化和细胞迁移。
KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair.
体内研究：
KLD-12 TFA (10-250 μg/rat，单剂量，骨折部位注射) 在股骨钻孔损伤的 Sprague-Dawley 大鼠模型中，剂量依赖地促进骨折部位的骨再生。Animal Model:Sprague-Dawley rats model with drill-hole injury in femur
Dosage:10-250 μg/rat
Administration:injection to the fracture site, single dose
Result:Increased osteoinduction and callus formation.
体外研究：
KLD-12 与 SDF-1 形成自组装多肽，提高骨髓基质细胞 (BMSC) 的存活率，通过 Wnt/β-catenin 通路促进 BMSC 成骨分化和细胞迁移。
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