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编 号：F610907
分子式：C28H21N5O
分子量：443.5
分子式：C28H21N5O
分子量：443.5
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CAS No: 853910-61-9
产品详情
生物活性：
NVP-BBD130 is a potent, stable, ATP-competitive and orally active dual PI3K and mTOR inhibitor. NVP-BBD130 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
NVP-BBD130 (40 mg/kg; p.o.; daily for 2 weeks) efficiently attenuates tumor growth at primary and lymph node metastatic sites with no obvious toxicity, and is well tolerant in B16BL6 mouse melanoma model.Animal Model:C57BL6 mice, syngeneic B16BL6 mouse melanoma model
Dosage:40 mg/kg
Administration:Oral administration, daily for 2 weeks
Result:Reduced primary tumor size, showed a significant reduction in the size of the cervical lymph node metastasis.
体外研究：
NVP-BBD130 (1 μM; 72 h) blocks proliferation of melanoma cells, arrests cell cycle at G1 phase in A2058 cells but not C32 cells.
NVP-BBD130 is a potent, stable, ATP-competitive and orally active dual PI3K and mTOR inhibitor. NVP-BBD130 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
NVP-BBD130 (40 mg/kg; p.o.; daily for 2 weeks) efficiently attenuates tumor growth at primary and lymph node metastatic sites with no obvious toxicity, and is well tolerant in B16BL6 mouse melanoma model.Animal Model:C57BL6 mice, syngeneic B16BL6 mouse melanoma model
Dosage:40 mg/kg
Administration:Oral administration, daily for 2 weeks
Result:Reduced primary tumor size, showed a significant reduction in the size of the cervical lymph node metastasis.
体外研究：
NVP-BBD130 (1 μM; 72 h) blocks proliferation of melanoma cells, arrests cell cycle at G1 phase in A2058 cells but not C32 cells.
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