产品
编 号：F610903
分子式：C17H13N3O3
分子量：307.3
分子式：C17H13N3O3
分子量：307.3
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 854171-31-6
产品详情
生物活性：
A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH.
体内研究：
A3334 (25 mg/kg; p.o. once daily for 16 weeks) has anti-obesity effects in the HFD mice, and has no effect on mice fed with normal diet.A3334 (25 mg/kg; p.o. once daily for 5 days) significantly reduces fasting glucose and the levels of glucose tolerance (GTT) and insulin tolerance (ITT) in serum in mice.A3334 (25 mg/kg; p.o. once daily for 3 weeks) significantly abolishes hepatosteatosis and the increased levels of alanine transaminase (ALT) and aspartatetransaminase (AST) in mice.Animal Model:Male C57BL/6N mice (6-week-old) are fed on the high fat die (HFD) for 16 weeks
Dosage:25 mg/kg
Administration:P.o. daily for 16 weeks
Result:Not observed the HFD-induced body weight gain and abdominal obesity.Reduced the level of triglyceride and total cholesterol and increased the level of HDL-cholesterol.Suppressed the increase in adipocyte cell sizes and enhancement of inflammation.
体外研究：
A3334 (1-10 μM) efficiently inhibits the adipogenic differentiation of 3T3-L1 preadipocytes via the Wnt/β-eatenin signaling pathway.A3334 (1-10 μM; 24 h) enhances the TOPFlash reporter activity in HEK293-TOP cells.
A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH.
体内研究：
A3334 (25 mg/kg; p.o. once daily for 16 weeks) has anti-obesity effects in the HFD mice, and has no effect on mice fed with normal diet.A3334 (25 mg/kg; p.o. once daily for 5 days) significantly reduces fasting glucose and the levels of glucose tolerance (GTT) and insulin tolerance (ITT) in serum in mice.A3334 (25 mg/kg; p.o. once daily for 3 weeks) significantly abolishes hepatosteatosis and the increased levels of alanine transaminase (ALT) and aspartatetransaminase (AST) in mice.Animal Model:Male C57BL/6N mice (6-week-old) are fed on the high fat die (HFD) for 16 weeks
Dosage:25 mg/kg
Administration:P.o. daily for 16 weeks
Result:Not observed the HFD-induced body weight gain and abdominal obesity.Reduced the level of triglyceride and total cholesterol and increased the level of HDL-cholesterol.Suppressed the increase in adipocyte cell sizes and enhancement of inflammation.
体外研究：
A3334 (1-10 μM) efficiently inhibits the adipogenic differentiation of 3T3-L1 preadipocytes via the Wnt/β-eatenin signaling pathway.A3334 (1-10 μM; 24 h) enhances the TOPFlash reporter activity in HEK293-TOP cells.
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