产品
编 号：F610701
分子式：C19H19N3O
分子量：305.37
分子式：C19H19N3O
分子量：305.37
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 865317-30-2
产品详情
生物活性：
CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent.
体内研究：
CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) 显示在裸鼠中的人 CRC 异种移植肿瘤中的抗肿瘤活性。Animal Model:Athymic nude mice
Dosage:8 mg/kg
Administration:Injections were given subcutaneously daily for the first week and every other day for two more weeks for a total of 14 injections.
Result:Reduced tumor growth and tumor weight in vivo.
体外研究：
CDK5 inhibitor 20-223 (10 nM-10 μM；72 h) 有效抑制一组结直肠癌 (CRC) 细胞系的细胞生长。CDK5 inhibitor 20-223 (0.3125 -20 μM；6 h) 在三种 CRC 细胞系中诱导 pRB (S807/811) 和 pFAK (S732) 水平的剂量依赖性降低。
CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent.
体内研究：
CDK5 inhibitor 20-223 (8mg/kg; subcutaneously; for 14 injections) 显示在裸鼠中的人 CRC 异种移植肿瘤中的抗肿瘤活性。Animal Model:Athymic nude mice
Dosage:8 mg/kg
Administration:Injections were given subcutaneously daily for the first week and every other day for two more weeks for a total of 14 injections.
Result:Reduced tumor growth and tumor weight in vivo.
体外研究：
CDK5 inhibitor 20-223 (10 nM-10 μM；72 h) 有效抑制一组结直肠癌 (CRC) 细胞系的细胞生长。CDK5 inhibitor 20-223 (0.3125 -20 μM；6 h) 在三种 CRC 细胞系中诱导 pRB (S807/811) 和 pFAK (S732) 水平的剂量依赖性降低。
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