产品
编 号：F610442
分子式：C24H17N3O5
分子量：427.41
分子式：C24H17N3O5
分子量：427.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 877950-01-1
产品详情
生物活性：
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.
体外研究：
LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group. LtaS-IN-1 is against Enterococcus spp 28 strains withvarying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strainE1630 andE1590 with the MIC values of 0.5μg/mL. LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growthby 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively.
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.
体外研究：
LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group. LtaS-IN-1 is against Enterococcus spp 28 strains withvarying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strainE1630 andE1590 with the MIC values of 0.5μg/mL. LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growthby 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively.
产品资料
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