产品
编 号：F609908
分子式：C33H44N6O4
分子量：588.74
分子式：C33H44N6O4
分子量：588.74
产品类型
规格
价格
是否有货
结构图
CAS No: 914291-61-5
产品详情
生物活性：
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation.
体外研究：
PS372424 (100?ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5?min of stimulation.PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells.PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC50 of 42±21 nM.
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation.
体外研究：
PS372424 (100?ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5?min of stimulation.PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells.PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC50 of 42±21 nM.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备