产品
编 号：F607030
分子式：C27H20N6O3
分子量：476.49
分子式：C27H20N6O3
分子量：476.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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询价
结构图
CAS No: 50440-30-7
产品详情
生物活性：
T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 μM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream).
体内研究：
T3Inh-1 (25 or 50 mg/kg; i.p.) blocks ppGalNAc-T3-mediated glycan-masking of FGF23 thereby increasing its cleavage.Animal Model:Wild-type C57BL/6 six to eight week old mice
Dosage:25 or 50 mg/kg
Administration:Intraperitoneal injection (Dissolved in DMSO at 25 and 50 mg/ml then further diluted with PEG400 to create 5 and 10 mg/ml stocks for injection)
Result:Caused a robust and statistically significant increase the ratio of cleaved/intact FGF23 at the tested 25 and 50 mg/kg concentrations.
体外研究：
T3Inh-1 (5 μM; 24-48 hours; 5 μM; MDA-MB231 cells) is strikingly effective, inhibiting migration by >80% and invasion by 98% while causing no discernable effect on cell proliferation. T3Inh-1 exhibits no toxicity and did not affect HEK cell proliferation.T3Inh-1 (HEK cells; 6 hours)increases cleavage of FGF23.
T3Inh-1 is a potent and selective inhibitor of ppGalNAc-T3 (IC50=7 μM). T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. T3Inh-1 also prevents breast cancer cells. The enzyme ppGalNAc-T3 is implicated in at least two medically important pathways: cancer metastasis and stabilization of FGF23 (regulates phosphate levels in the bloodstream).
体内研究：
T3Inh-1 (25 or 50 mg/kg; i.p.) blocks ppGalNAc-T3-mediated glycan-masking of FGF23 thereby increasing its cleavage.Animal Model:Wild-type C57BL/6 six to eight week old mice
Dosage:25 or 50 mg/kg
Administration:Intraperitoneal injection (Dissolved in DMSO at 25 and 50 mg/ml then further diluted with PEG400 to create 5 and 10 mg/ml stocks for injection)
Result:Caused a robust and statistically significant increase the ratio of cleaved/intact FGF23 at the tested 25 and 50 mg/kg concentrations.
体外研究：
T3Inh-1 (5 μM; 24-48 hours; 5 μM; MDA-MB231 cells) is strikingly effective, inhibiting migration by >80% and invasion by 98% while causing no discernable effect on cell proliferation. T3Inh-1 exhibits no toxicity and did not affect HEK cell proliferation.T3Inh-1 (HEK cells; 6 hours)increases cleavage of FGF23.
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