产品
编 号：F605752
分子式：C24H41NO3
分子量：391.59
分子式：C24H41NO3
分子量：391.59
产品类型
规格
价格
是否有货
结构图
CAS No: 69693-13-6
产品详情
生物活性：
Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects.
体内研究：
Palvanil (subcutaneous injection; 1 or 10 mg/kg; once) treatment shows hypothermic effect.Palvanil (intraperitoneal injection; 100 μL (15 nM) per mouse; once) treatment reduces Capsaicin-induced bronchoconstriction.Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment shows antinociceptive effects on Formalin-induced nocifensive behavior.Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment inhibits Carrageenan-induced inflammation.Palvanil (intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days) reduces mechanical allodynia and thermal hyperalgesia inspared nerve injury (SNI) mice.Animal Model:Male CD-1 mice
Dosage:1 or 10 mg/kg
Administration:Subcutaneous injection; 1 or 10 mg/kg; once
Result:Led to a slight and short lasting hypothermic effect, produced late hyperthermia.
Animal Model:Female BALB/C mice
Dosage:100 μL (15 nM) per mouse
Administration:Intraperitoneal injection; 100 μL (15 nM) per mouse; once
Result:Induced a significantly lower bronchoconstriction (from 0.47 to 0.605 cm H2O/L/s).
Animal Model:Male CD-1 mice received formalin
Dosage:0.5, 0.75, and 1 mg/kg
Administration:Intravenous injection; 0.5, 0.75, and 1 mg/kg; once
Result:Reduced the second phase of Formalin-induced nociceptive behaviour in a dose-dependent manner.
Animal Model:Male C57BL/6J mice with acute inflammation induced by Carrageenan
Dosage:2.5 mg/kg
Administration:Intravenous injection; 2.5 mg/kg; once
Result:Reduced the volume of the oedema in the ipsilateral hind paw (64%).
Animal Model:Male CD-1 mice
Dosage:0.5 and 1 mg/kg
Administration:Intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days
Result:Reduced mechanical allodynia and thermal hyperalgesia at 3 and 7 days after nerve injury in a dose-dependent manner.
体外研究：
Palvanil (0.1-1000 nM; 0-300 min) leads to calcium increasment in HEK-293 intracellular.Palvanil (1-10 nM; 5 min) treatment desensitizes TRPV1 to the effect of Capsaicin significantly.
Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects.
体内研究：
Palvanil (subcutaneous injection; 1 or 10 mg/kg; once) treatment shows hypothermic effect.Palvanil (intraperitoneal injection; 100 μL (15 nM) per mouse; once) treatment reduces Capsaicin-induced bronchoconstriction.Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment shows antinociceptive effects on Formalin-induced nocifensive behavior.Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment inhibits Carrageenan-induced inflammation.Palvanil (intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days) reduces mechanical allodynia and thermal hyperalgesia inspared nerve injury (SNI) mice.Animal Model:Male CD-1 mice
Dosage:1 or 10 mg/kg
Administration:Subcutaneous injection; 1 or 10 mg/kg; once
Result:Led to a slight and short lasting hypothermic effect, produced late hyperthermia.
Animal Model:Female BALB/C mice
Dosage:100 μL (15 nM) per mouse
Administration:Intraperitoneal injection; 100 μL (15 nM) per mouse; once
Result:Induced a significantly lower bronchoconstriction (from 0.47 to 0.605 cm H2O/L/s).
Animal Model:Male CD-1 mice received formalin
Dosage:0.5, 0.75, and 1 mg/kg
Administration:Intravenous injection; 0.5, 0.75, and 1 mg/kg; once
Result:Reduced the second phase of Formalin-induced nociceptive behaviour in a dose-dependent manner.
Animal Model:Male C57BL/6J mice with acute inflammation induced by Carrageenan
Dosage:2.5 mg/kg
Administration:Intravenous injection; 2.5 mg/kg; once
Result:Reduced the volume of the oedema in the ipsilateral hind paw (64%).
Animal Model:Male CD-1 mice
Dosage:0.5 and 1 mg/kg
Administration:Intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days
Result:Reduced mechanical allodynia and thermal hyperalgesia at 3 and 7 days after nerve injury in a dose-dependent manner.
体外研究：
Palvanil (0.1-1000 nM; 0-300 min) leads to calcium increasment in HEK-293 intracellular.Palvanil (1-10 nM; 5 min) treatment desensitizes TRPV1 to the effect of Capsaicin significantly.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备