产品
编 号：F604584
分子式：C183H293N47O59
分子量：4095.63
分子式：C183H293N47O59
分子量：4095.63
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CAS No: 93438-37-0
产品详情
生物活性：
Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.
体内研究：
Helospectin I (0.03-2 nmol/kg, 100 μL of infusion at the left jugular vein) reduces blood pressure in rats.Helospectin I (0.1-0.8 nmol /kg, i.v.) increases plasma levels of glucagon in mice.Animal Model:SD rats
Dosage:0.03, 0.3, 1, 2 nM/kg
Administration:100 μL of infusion at the left jugular vein, followed by washing the catheter with 100 μL saline.
Result:Reduced the blood pressure, but was less effective than vasoactive intestinal peptide (VIP) in the low dose range.
Animal Model:Mice
Dosage:0.1, 0.2, 0.4, 0.8 nM /kg
Administration:Intravenous injection (i.v.)
Result:Markedly stimulated glucagon secretion, and had no direct action on insulin secretion.
体外研究：
Helospectin I (suffusion at 0.1 nM, in bicarbonate buffer for 30 min) evokes significant, sustained and similar vasodilation in the intact hamster cheek pouch.Helospectin I relaxes the Phenylephrine-contracted rat femoral arteries with pEC50 of 6.82.Helospectin I (0.1 nM-1 μM) inhibits the binding of 125I-labeled VIP and 125I-secretin to dispersed chief cells.
Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.
体内研究：
Helospectin I (0.03-2 nmol/kg, 100 μL of infusion at the left jugular vein) reduces blood pressure in rats.Helospectin I (0.1-0.8 nmol /kg, i.v.) increases plasma levels of glucagon in mice.Animal Model:SD rats
Dosage:0.03, 0.3, 1, 2 nM/kg
Administration:100 μL of infusion at the left jugular vein, followed by washing the catheter with 100 μL saline.
Result:Reduced the blood pressure, but was less effective than vasoactive intestinal peptide (VIP) in the low dose range.
Animal Model:Mice
Dosage:0.1, 0.2, 0.4, 0.8 nM /kg
Administration:Intravenous injection (i.v.)
Result:Markedly stimulated glucagon secretion, and had no direct action on insulin secretion.
体外研究：
Helospectin I (suffusion at 0.1 nM, in bicarbonate buffer for 30 min) evokes significant, sustained and similar vasodilation in the intact hamster cheek pouch.Helospectin I relaxes the Phenylephrine-contracted rat femoral arteries with pEC50 of 6.82.Helospectin I (0.1 nM-1 μM) inhibits the binding of 125I-labeled VIP and 125I-secretin to dispersed chief cells.
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