产品
编 号：F604568
分子式：C180H288N46O57
分子量：4008.55
分子式：C180H288N46O57
分子量：4008.55
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CAS No: 93585-83-2
产品详情
生物活性：
Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.
体内研究：
Helospectin II (0.03-2 nmol/kg, 100 μL of infusion at the left jugular vein) reduces blood pressure in rats.Animal Model:SD rats
Dosage:0.03, 0.3, 1, 2 nmol/kg
Administration:100 μL of infusion at the left jugular vein, followed by washing the catheter with 100 μL saline.
Result:Reduced the blood pressure, but was less effective than vasoactive intestinal peptide (VIP) in the low dose range.
体外研究：
Helospectin II (suffusion at 0.1 nM, in bicarbonate buffer for 30 min) evokes significant, sustained and similar vasodilation in the intact hamster cheek pouch.Helospectin II relaxes the Phenylephrine-contracted rat femoral arteries with pEC50 of 6.93.
Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.
体内研究：
Helospectin II (0.03-2 nmol/kg, 100 μL of infusion at the left jugular vein) reduces blood pressure in rats.Animal Model:SD rats
Dosage:0.03, 0.3, 1, 2 nmol/kg
Administration:100 μL of infusion at the left jugular vein, followed by washing the catheter with 100 μL saline.
Result:Reduced the blood pressure, but was less effective than vasoactive intestinal peptide (VIP) in the low dose range.
体外研究：
Helospectin II (suffusion at 0.1 nM, in bicarbonate buffer for 30 min) evokes significant, sustained and similar vasodilation in the intact hamster cheek pouch.Helospectin II relaxes the Phenylephrine-contracted rat femoral arteries with pEC50 of 6.93.
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