产品
编 号：F603944
分子式：C19H23ClN2S
分子量：346.92
分子式：C19H23ClN2S
分子量：346.92
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
250mg
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询价
结构图
CAS No: 2975-36-2
产品详情
生物活性：
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.
体内研究：
Mepazine (16 mg/kg；腹膜内给药) 干扰 NOD/scid IL-2RgnuLl (NSG) 小鼠的 ABC-DLBCL 细胞系 OCI-Ly10 的生长并诱导细胞凋亡模型。每天服用 Mepazine 会严重损害 ABC-DLBCL 细胞系 OCI-Ly10 的扩增。Animal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model
Dosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg
Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application
Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
体外研究：
Mepazine (5 -20 μM；4 天) 导致弥漫性大 B 细胞淋巴瘤 (ABCDLBCL) 细胞活化 B 细胞亚型的细胞活力降低，但对 GCB-DLBCL 细胞没有显着影响。
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis.
体内研究：
Mepazine (16 mg/kg；腹膜内给药) 干扰 NOD/scid IL-2RgnuLl (NSG) 小鼠的 ABC-DLBCL 细胞系 OCI-Ly10 的生长并诱导细胞凋亡模型。每天服用 Mepazine 会严重损害 ABC-DLBCL 细胞系 OCI-Ly10 的扩增。Animal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model
Dosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg
Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application
Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
体外研究：
Mepazine (5 -20 μM；4 天) 导致弥漫性大 B 细胞淋巴瘤 (ABCDLBCL) 细胞活化 B 细胞亚型的细胞活力降低，但对 GCB-DLBCL 细胞没有显着影响。
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