产品
编 号：F603406
分子式：C13H19N5O2S2
分子量：341.45
分子式：C13H19N5O2S2
分子量：341.45
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 6505-99-3
产品详情
生物活性：
JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death.
体外研究：
JA2131 (10 mM; 1-2 h) induces hyperPARylation of PARP1 in PC3 cells.JA2131 (10 μM; 2 wk) inhibits colony formation of MCF-7, PC3, and MDA-MB-231 cells, and (0.1 μM-1 mM; 72 h) shows cytotoxicity to inhibit MRC-50 cells with an IC50 value of 132 μM.JA2131 (5 μM; 72 h) inhibits PC3, and A172 glioblastoma cells viability.JA2131 (10 μM; 2 h) could be acting at the replication fork in HeLa cells.
JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death.
体外研究：
JA2131 (10 mM; 1-2 h) induces hyperPARylation of PARP1 in PC3 cells.JA2131 (10 μM; 2 wk) inhibits colony formation of MCF-7, PC3, and MDA-MB-231 cells, and (0.1 μM-1 mM; 72 h) shows cytotoxicity to inhibit MRC-50 cells with an IC50 value of 132 μM.JA2131 (5 μM; 72 h) inhibits PC3, and A172 glioblastoma cells viability.JA2131 (10 μM; 2 h) could be acting at the replication fork in HeLa cells.
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