产品
编 号：F603038
分子式：C22H34O2
分子量：330.5
分子式：C22H34O2
分子量：330.5
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 511-26-2
产品详情
生物活性：
MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents.
体内研究：
MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats.MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats.Animal Model:Adult Sprague-Dawley male rats with spinal cord injury
Dosage:12 mg/kg
Administration:Daily s.c. for 28 days
Result:Increased the number of animals able to walk with weight-supported plantar steps.Showed forelimb-hindlimb coordination at the end of the study.
体外研究：
MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro.MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells
MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents.
体内研究：
MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats.MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats.Animal Model:Adult Sprague-Dawley male rats with spinal cord injury
Dosage:12 mg/kg
Administration:Daily s.c. for 28 days
Result:Increased the number of animals able to walk with weight-supported plantar steps.Showed forelimb-hindlimb coordination at the end of the study.
体外研究：
MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro.MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells
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