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编 号：F602654
分子式：C54H71N11O10S2
分子量：1098.34
分子式：C54H71N11O10S2
分子量：1098.34
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CAS No: 113294-82-9
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生物活性：
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26?nM and 6.92?nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research.
体内研究：
Angiopeptin (20 and 50μg/kg; i.h.) significantly inhibits neointimal formation.Angiopeptin (20 μg/kg; per day) significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%.
体外研究：
Angiopeptin (0.1 nM- 10 μM; for 1?h) acts as a partial agonist (pEC50=6.57) with a maximum response of 423% at 3?μM on the release of tritium on CHO hsst2 cells.
Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26?nM and 6.92?nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research.
体内研究：
Angiopeptin (20 and 50μg/kg; i.h.) significantly inhibits neointimal formation.Angiopeptin (20 μg/kg; per day) significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%.
体外研究：
Angiopeptin (0.1 nM- 10 μM; for 1?h) acts as a partial agonist (pEC50=6.57) with a maximum response of 423% at 3?μM on the release of tritium on CHO hsst2 cells.
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