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编 号：F602568
分子式：C24H30Cl2FN3O3
分子量：498.42
分子式：C24H30Cl2FN3O3
分子量：498.42
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CAS No: 380449-51-4
产品详情
生物活性：
Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells.
体内研究：
Melflufen (Melphalan flufenamide) (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model.Animal Model:CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model)
Dosage:3 mg/kg
Administration:I.v.; twice-weekly for two weeks
Result:Significantly inhibited MM tumor growth and prolonged survival of mice.
体外研究：
Melflufen (Melphalan flufenamide) (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner.Melflufen induces apoptosis in MM.1S cells.Melphalan also is a potent activator of exosome secretion.
Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells.
体内研究：
Melflufen (Melphalan flufenamide) (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model.Animal Model:CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model)
Dosage:3 mg/kg
Administration:I.v.; twice-weekly for two weeks
Result:Significantly inhibited MM tumor growth and prolonged survival of mice.
体外研究：
Melflufen (Melphalan flufenamide) (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner.Melflufen induces apoptosis in MM.1S cells.Melphalan also is a potent activator of exosome secretion.
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