产品
编 号:F601890
分子式:C22H21ClN2O4
分子量:412.87
产品类型
结构图
CAS No: 2349374-37-2
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产品详情
生物活性:
15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation.
体外研究:
15-LOX-1 inhibitor 1 (Compound 9c) (0-5?μM; 24 hours) protects RAW 264.7 macrophages from LPS-induced cell death and shows stronger, dose-dependent effects with a 20% viability increase at 5 μM.