产品
编 号：F064207
分子式：C43H79NO2
分子量：642.09
分子式：C43H79NO2
分子量：642.09
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1190197-97-7
产品详情
生物活性：
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies.
体内研究：
DLin-KC2-DMA contained-LNP siRNA systems (5 mg/kg; i.v.; single) effectively silences target genes in APcs in vivo.Animal Model:Naive C57BL/6 mice.
Dosage:3 or 5 mg/kg (DLin-KC2-DMA contained-LNPs)
Administration:Intravenous injection; single.
Result:Significantly reduced GAPDH production in peritoneal cavity macrophages and dendritic cells and in the spleen-derived APCs when at 5 mg/kg.
体外研究：
DLin-KC2-DMA (1, 5 μg; 72 h) effectively produces a significant siRNA-mediated GAPDH gene silencing in both macrophages and dendritic cells.DLin-KC2-DMA (24 h) exhibits high uptake into macrophages and dendritic cells.DLin-KC2-DMA efficiently promotes release of encapsulated siRNA into the cytosol following uptake via the endocytotic pathway.DLin-KC2-DMA displays almost no toxicity in primary APCs.
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies.
体内研究：
DLin-KC2-DMA contained-LNP siRNA systems (5 mg/kg; i.v.; single) effectively silences target genes in APcs in vivo.Animal Model:Naive C57BL/6 mice.
Dosage:3 or 5 mg/kg (DLin-KC2-DMA contained-LNPs)
Administration:Intravenous injection; single.
Result:Significantly reduced GAPDH production in peritoneal cavity macrophages and dendritic cells and in the spleen-derived APCs when at 5 mg/kg.
体外研究：
DLin-KC2-DMA (1, 5 μg; 72 h) effectively produces a significant siRNA-mediated GAPDH gene silencing in both macrophages and dendritic cells.DLin-KC2-DMA (24 h) exhibits high uptake into macrophages and dendritic cells.DLin-KC2-DMA efficiently promotes release of encapsulated siRNA into the cytosol following uptake via the endocytotic pathway.DLin-KC2-DMA displays almost no toxicity in primary APCs.
产品资料
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