产品
编 号：F601772
分子式：C63H118N18O14S
分子量：1383.81
分子式：C63H118N18O14S
分子量：1383.81
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CAS No: 1423381-07-0
产品详情
生物活性：
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC).
体内研究：
Pep2m, myristoylated (10 μg/20 μL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test.Animal Model:Female and male Long-Evans hooded rats (8 weeks)
Dosage:10 μg (in 20 μL)
Administration:Intrathecal injection
Result:Resulted in an increase in PWTs, in both male and female rats at various time points tested.
体外研究：
Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC).
体内研究：
Pep2m, myristoylated (10 μg/20 μL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test.Animal Model:Female and male Long-Evans hooded rats (8 weeks)
Dosage:10 μg (in 20 μL)
Administration:Intrathecal injection
Result:Resulted in an increase in PWTs, in both male and female rats at various time points tested.
体外研究：
Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.
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