产品
编 号：F601770
分子式：C15H14O6S
分子量：322.33
分子式：C15H14O6S
分子量：322.33
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1227401-27-5
产品详情
生物活性：
GN25 is a specific p53-Snail binding inhibitor with antitumor effects.
体内研究：
GN25 (10 and 20 mg/kg; i.p. once a week for 10 weeks) blocks the tumor progression and induces tumor regression in mice.Animal Model:Athymic mice with A549 xenografts
Dosage:10 and 20 mg/kg
Administration:Intraperitoneal injection; once a week for 10 weeks
Result:Obviously regressed tumors in mice. Showed no significant toxicity in liver, pancreas and kidney.
体外研究：
GN25 (10 and 20 μM; 24 h) inhibits cell viability of K-Ras-mutated MEF cells.GN25 (5 μM; 4 h) activates p53 in a K-Ras-dependent manner.GN25 (1-10 μM; 1-6 h) induces p53 and p21 in a dose- and time- dependent manner in K-Ras-mutated A549 and HCT116 cell lines.GN25 activates wild-type p53 in p53WT/MT cells.GN25 (0.25 μM) recovers the masking effect of p53 on CK1/GSK3b-mediated Snail phosphorylation.
GN25 is a specific p53-Snail binding inhibitor with antitumor effects.
体内研究：
GN25 (10 and 20 mg/kg; i.p. once a week for 10 weeks) blocks the tumor progression and induces tumor regression in mice.Animal Model:Athymic mice with A549 xenografts
Dosage:10 and 20 mg/kg
Administration:Intraperitoneal injection; once a week for 10 weeks
Result:Obviously regressed tumors in mice. Showed no significant toxicity in liver, pancreas and kidney.
体外研究：
GN25 (10 and 20 μM; 24 h) inhibits cell viability of K-Ras-mutated MEF cells.GN25 (5 μM; 4 h) activates p53 in a K-Ras-dependent manner.GN25 (1-10 μM; 1-6 h) induces p53 and p21 in a dose- and time- dependent manner in K-Ras-mutated A549 and HCT116 cell lines.GN25 activates wild-type p53 in p53WT/MT cells.GN25 (0.25 μM) recovers the masking effect of p53 on CK1/GSK3b-mediated Snail phosphorylation.
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