产品
编 号：F601694
分子式：C24H27FN6O3
分子量：466.51
分子式：C24H27FN6O3
分子量：466.51
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CAS No: 2095107-57-4
产品详情
生物活性：
AFM-30a is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
体内研究：
AFM-30a suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice.
体外研究：
AFM-30a (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC50 of 9.5 μM.AFM-30a shows good ability to inhibit H3 citrullination with an EC50 of 0.4 μM.
AFM-30a is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
体内研究：
AFM-30a suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice.
体外研究：
AFM-30a (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC50 of 9.5 μM.AFM-30a shows good ability to inhibit H3 citrullination with an EC50 of 0.4 μM.
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