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编 号:F601679
分子式:C24H24N4O4
分子量:432.47
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生物活性:
RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5.

体内研究:
RP-001 causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg.

体外研究:
RP-001 elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 induces acute lymphopenia with rapid recovery to untreated levels.
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