产品
编 号：F601627
分子式：C17H20F3N3O3
分子量：371.35
分子式：C17H20F3N3O3
分子量：371.35
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 1208549-68-1
产品详情
生物活性：
sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively.
体内研究：
Pharmacokinetic parameters of sEH inhibitor-1 (TCPU) after oral gavage with a non-compartmental analysis.Doses (mg/kg)Cmaxa (nmol/L)Tmax (h)aAUCt (uM?h)aMRT (h)a
0.1 (0.27d)270±1205.3±1.22.2±1.118.9±6.6
0.3 (0.81d)1680±11704.7±1.216.6±8.816.9±5.4
1.0 (2.69d)2560±953.2±2.243.8±5.124.0±1.8
3.0 (8.08d)5160±2653.9±2.594.3±8.032.1±5.6
a: Tmax, the time of maximum concentration; Cmax, the maximum blood concentration; MRT, the mean residence time; and AUCt, area under the concentration–time curve to terminal time. Additional PK parameters with non-compartmental model are presented in Table S3.d: The dose with the unit of μmol/kg.
sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of sEH (soluble epoxide hydrolase) with IC50s of 0.4 and 5.3 nM in human and murine, respectively.
体内研究：
Pharmacokinetic parameters of sEH inhibitor-1 (TCPU) after oral gavage with a non-compartmental analysis.Doses (mg/kg)Cmaxa (nmol/L)Tmax (h)aAUCt (uM?h)aMRT (h)a
0.1 (0.27d)270±1205.3±1.22.2±1.118.9±6.6
0.3 (0.81d)1680±11704.7±1.216.6±8.816.9±5.4
1.0 (2.69d)2560±953.2±2.243.8±5.124.0±1.8
3.0 (8.08d)5160±2653.9±2.594.3±8.032.1±5.6
a: Tmax, the time of maximum concentration; Cmax, the maximum blood concentration; MRT, the mean residence time; and AUCt, area under the concentration–time curve to terminal time. Additional PK parameters with non-compartmental model are presented in Table S3.d: The dose with the unit of μmol/kg.
产品资料
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