产品
编 号：F601440
分子式：C32H23ClN2O4
分子量：534.99
分子式：C32H23ClN2O4
分子量：534.99
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CAS No: 1453835-43-2
产品详情
生物活性：
LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM).
体内研究：
LLP-3 (intraperitoneal injection, 25 mg/kg, for 10 days) prolongs survival of GBM sphere-derived tumor mice.Animal Model:GBM sphere-derived tumor models (GBM83 and 1600)
Dosage:25 mg/kg
Administration:Intraperitoneal injection, for 10 days (days 10–14 and days 17–21)
Result:Prolonged the survival of tumor-burden mice without exhibiting any lethality of mice until day 35.
体外研究：
LLP-3 (20 μM, 24 h) impaires the binding of Survivin to Smac/DIABLO (proapoptotic protein), without affecting the interaction of Survivin with other chromosomal passenger complex (CPC) proteins.LLP-3 (20 μM, 24 h) decreases the Survivin-Ran interaction in U87 cells.LLP-3 (20 μM, 24 h) arrests cell in G0-G1 phase and subsequent tumor cell death.LLP-3 (20 μM, 24 h) triggers caspase-dependent apoptosis in HT1080 cells.LLP-3 (0-100 μM, 72 h) inhibits tumor cells survival by p53-mediated inhibition.
LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM).
体内研究：
LLP-3 (intraperitoneal injection, 25 mg/kg, for 10 days) prolongs survival of GBM sphere-derived tumor mice.Animal Model:GBM sphere-derived tumor models (GBM83 and 1600)
Dosage:25 mg/kg
Administration:Intraperitoneal injection, for 10 days (days 10–14 and days 17–21)
Result:Prolonged the survival of tumor-burden mice without exhibiting any lethality of mice until day 35.
体外研究：
LLP-3 (20 μM, 24 h) impaires the binding of Survivin to Smac/DIABLO (proapoptotic protein), without affecting the interaction of Survivin with other chromosomal passenger complex (CPC) proteins.LLP-3 (20 μM, 24 h) decreases the Survivin-Ran interaction in U87 cells.LLP-3 (20 μM, 24 h) arrests cell in G0-G1 phase and subsequent tumor cell death.LLP-3 (20 μM, 24 h) triggers caspase-dependent apoptosis in HT1080 cells.LLP-3 (0-100 μM, 72 h) inhibits tumor cells survival by p53-mediated inhibition.
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