产品
编 号：F601359
分子式：C32H47N3O9S
分子量：649.8
分子式：C32H47N3O9S
分子量：649.8
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CAS No: 1810710-59-8
产品详情
生物活性：
PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs).
体内研究：
PCTR1, a lipid mediator, exerts fundamental anti-inflammation and pro-resolution during infection.PCTR1 (50?ng/mice) improves the survival rate in an LPS-induced acute inflammatory mouse model.Animal Model:C57BL/6J wild-type male mice (8-10 weeks old, 22-25?g)
Dosage:50?ng/mice
Administration:Administered via the tail vein 1?h after LPS (15?mg/kg) intraperitoneal injection. The survival rate was recorded every day for 7 days
Result:Compared with the LPS group, the survival rate was significantly higher in the LPS?+?PCTR1 group, indicating that PCTR1 markedly increases the survival rate.
体外研究：
PCTR1 is a peptide-containing lipid mediator. PCTR1 is temporally regulated during self-limited inflammation and promotes the resolution of bacterial infection. PCTR1 significantly decreases prostaglandin (PG)E2 (48%), PGD2 (64%), PGF2α (38%), and thromboxane B2 (40%). PCTR1 increases exudate macrophage levels, accelerates clearance of E. coli infection, decreases local inflammatory mediator production, and promotes resolution.PCTR1 is an agonist of human keratinocyte migration and has unique structural features that impart this agonist activity. PCTR1 enhances human keratinocyte migration in a cAMP/PKA-dependent manner. Stimulation of keratinocytes with PCTR1 (10 nM; 15 minutes) significantly elevates levels of cAMP.
PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs).
体内研究：
PCTR1, a lipid mediator, exerts fundamental anti-inflammation and pro-resolution during infection.PCTR1 (50?ng/mice) improves the survival rate in an LPS-induced acute inflammatory mouse model.Animal Model:C57BL/6J wild-type male mice (8-10 weeks old, 22-25?g)
Dosage:50?ng/mice
Administration:Administered via the tail vein 1?h after LPS (15?mg/kg) intraperitoneal injection. The survival rate was recorded every day for 7 days
Result:Compared with the LPS group, the survival rate was significantly higher in the LPS?+?PCTR1 group, indicating that PCTR1 markedly increases the survival rate.
体外研究：
PCTR1 is a peptide-containing lipid mediator. PCTR1 is temporally regulated during self-limited inflammation and promotes the resolution of bacterial infection. PCTR1 significantly decreases prostaglandin (PG)E2 (48%), PGD2 (64%), PGF2α (38%), and thromboxane B2 (40%). PCTR1 increases exudate macrophage levels, accelerates clearance of E. coli infection, decreases local inflammatory mediator production, and promotes resolution.PCTR1 is an agonist of human keratinocyte migration and has unique structural features that impart this agonist activity. PCTR1 enhances human keratinocyte migration in a cAMP/PKA-dependent manner. Stimulation of keratinocytes with PCTR1 (10 nM; 15 minutes) significantly elevates levels of cAMP.
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