产品
编 号：F601321
分子式：C6H8N2O2
分子量：140.14
分子式：C6H8N2O2
分子量：140.14
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 1331754-16-5
产品详情
生物活性：
A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase.
体内研究：
A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats
体外研究：
A6770 causes concentration-dependent increases in [3H] dhS1P with the EC50 ranging from 30 to 200 μM under the normal condition. A6770 leads to S1PL inhibition rather than SPHK activation or SPP inhibition.
A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase.
体内研究：
A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats
体外研究：
A6770 causes concentration-dependent increases in [3H] dhS1P with the EC50 ranging from 30 to 200 μM under the normal condition. A6770 leads to S1PL inhibition rather than SPHK activation or SPP inhibition.
产品资料
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