产品
编 号：F601096
分子式：C6H23N3O7P2
分子量：311.21
分子式：C6H23N3O7P2
分子量：311.21
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CAS No: 933030-60-5
产品详情
生物活性：
(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release).
体内研究：
(E)-C-HDMAPP (化合物 5E) (0.02-10 mg/kg；静脉注射；15 天) 显着增加食蟹猴模型中的 γδ 细胞。Animal Model:Nonhuman Primate Model in Cynomolgus
Dosage:0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg, and 10 mg/kg
Administration:Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
Result:Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 5 mg/kg and 10 mg/kg.
体外研究：
(E)-C-HDMAPP (化合物 5E) (2 μM) 增加原代多克隆人 Vγ9Vδ2 T 细胞中的 TNF-α 释放水平，并具有刺激性生物活性。
(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release).
体内研究：
(E)-C-HDMAPP (化合物 5E) (0.02-10 mg/kg；静脉注射；15 天) 显着增加食蟹猴模型中的 γδ 细胞。Animal Model:Nonhuman Primate Model in Cynomolgus
Dosage:0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg, and 10 mg/kg
Administration:Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
Result:Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 5 mg/kg and 10 mg/kg.
体外研究：
(E)-C-HDMAPP (化合物 5E) (2 μM) 增加原代多克隆人 Vγ9Vδ2 T 细胞中的 TNF-α 释放水平，并具有刺激性生物活性。
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