产品
编 号：F601048
分子式：C42H61N5O11
分子量：811.96
分子式：C42H61N5O11
分子量：811.96
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CAS No: 130325-35-8
产品详情
生物活性：
PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity.
体内研究：
PD 135158 (CAM 1028; 0.001-0.1 mg/kg; s.c.; once) 增强大鼠的潜在抑制作用，显示出抗精神病潜能。Animal Model:Male Sprague-Dawley rats, conditioned suppression of drinking procedure model
Dosage:0.001, 0. 01, and 0.1 mg/kg
Administration:0.2 mL/kg SC 30 min before prexposure and conditioning
Result:Elicited a clear latent inhibition effect under conditions that did not lead to latent inhibition in control rats.
PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity.
体内研究：
PD 135158 (CAM 1028; 0.001-0.1 mg/kg; s.c.; once) 增强大鼠的潜在抑制作用，显示出抗精神病潜能。Animal Model:Male Sprague-Dawley rats, conditioned suppression of drinking procedure model
Dosage:0.001, 0. 01, and 0.1 mg/kg
Administration:0.2 mL/kg SC 30 min before prexposure and conditioning
Result:Elicited a clear latent inhibition effect under conditions that did not lead to latent inhibition in control rats.
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