产品
编 号：F600845
分子式：C82H137N31O22
分子量：1909.16
分子式：C82H137N31O22
分子量：1909.16
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CAS No: 236098-40-1
产品详情
生物活性：
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively.
体内研究：
In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice.
体外研究：
[Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects.
[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively.
体内研究：
In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice.
体外研究：
[Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects.
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