产品
编 号：F600842
分子式：C33H42O4
分子量：502.68
分子式：C33H42O4
分子量：502.68
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CAS No: 351416-47-2
产品详情
生物活性：
Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells.
体内研究：
Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts.Animal Model:Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor
Dosage:50 mg/kg
Administration:Daily i.p. injections for 28 days
Result:Showed a significant growth-inhibitory effect in pancreatic cancer xenografts.
体外研究：
Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells.Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines.
Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells.
体内研究：
Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts.Animal Model:Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor
Dosage:50 mg/kg
Administration:Daily i.p. injections for 28 days
Result:Showed a significant growth-inhibitory effect in pancreatic cancer xenografts.
体外研究：
Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells.Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines.
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