产品
编 号：F600621
分子式：C32H48Cl3N3O3
分子量：629.1
分子式：C32H48Cl3N3O3
分子量：629.1
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 848035-21-2
产品详情
生物活性：
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
体内研究：
Compound 48/80 trihydrochloride (0.75 mg/kg；腹腔注射；在 0.5、3 或 6 小时后被杀死) 在 0.5 小时增加血清血清素、组胺和皮质酮水平，但此后它们的增加量减少。 Compound 48/80 trihydrochloride 通过肥大细胞脱颗粒引起大鼠肾上腺氧化应激。Animal Model:7-week-old Wistar male rats (fasted for 24 hours)
Dosage:0.75 mg/kg
Administration:Intraperitoneal injection; Killed after 0.5, 3 or 6 h
Result:Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.
体外研究：
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 以相似的效率抑制细胞溶质和颗粒磷脂酰肌醇特异性磷脂酶 C 活性；IC50 值为 2.1 μg/mL (上清液) 和 5.0 μg/mL (颗粒部分)。Compound 48/80 trihydrochloride 可抑制 ADP 和 PAF-acether 诱导的人血小板聚集。
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
体内研究：
Compound 48/80 trihydrochloride (0.75 mg/kg；腹腔注射；在 0.5、3 或 6 小时后被杀死) 在 0.5 小时增加血清血清素、组胺和皮质酮水平，但此后它们的增加量减少。 Compound 48/80 trihydrochloride 通过肥大细胞脱颗粒引起大鼠肾上腺氧化应激。Animal Model:7-week-old Wistar male rats (fasted for 24 hours)
Dosage:0.75 mg/kg
Administration:Intraperitoneal injection; Killed after 0.5, 3 or 6 h
Result:Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.
体外研究：
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 以相似的效率抑制细胞溶质和颗粒磷脂酰肌醇特异性磷脂酶 C 活性；IC50 值为 2.1 μg/mL (上清液) 和 5.0 μg/mL (颗粒部分)。Compound 48/80 trihydrochloride 可抑制 ADP 和 PAF-acether 诱导的人血小板聚集。
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