产品
编 号：F600311
分子式：C24H34O6
分子量：418.52
分子式：C24H34O6
分子量：418.52
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CAS No: 730960-98-2
产品详情
生物活性：
NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling.
体外研究：
NSC15520 (10- 0.5 -10-3.5 M) 抑制 RPA 与 GST-p53 肽的相互作用，IC50 为 10 μM。Nsc15520 (0-400 μM; 5 min) 抑制螺旋不稳定活性。Nsc15520 (0-400 μM; 5 min) 抑制 RPA 结合 dsDNA 30-mer。
NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling.
体外研究：
NSC15520 (10- 0.5 -10-3.5 M) 抑制 RPA 与 GST-p53 肽的相互作用，IC50 为 10 μM。Nsc15520 (0-400 μM; 5 min) 抑制螺旋不稳定活性。Nsc15520 (0-400 μM; 5 min) 抑制 RPA 结合 dsDNA 30-mer。
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