产品
编 号：F600191
分子式：C16H31ClO2
分子量：290.87
分子式：C16H31ClO2
分子量：290.87
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 19117-92-1
产品详情
生物活性：
2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3.
体外研究：
2-Chlorohexadecanoic acid (2-ClHA; 10?μM; 4, 6 h) results phosphorylation of eIF2α starting 4?h post treatment, while total eIF2α levels remained unchanged incubation of hCMEC/D3 cells. 2-Chlorohexadecanoic acid increases expression of ATF4, a target gene of eIF2α. 2-Chlorohexadecanoic acid (25?μM, 30?min) induces a decrease in the FRET ratio signal of ERAT by 40%, indicating significantly diminished [ATP]ER?in cells that were treated with 2-Chlorohexadecanoic acid.
2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3.
体外研究：
2-Chlorohexadecanoic acid (2-ClHA; 10?μM; 4, 6 h) results phosphorylation of eIF2α starting 4?h post treatment, while total eIF2α levels remained unchanged incubation of hCMEC/D3 cells. 2-Chlorohexadecanoic acid increases expression of ATF4, a target gene of eIF2α. 2-Chlorohexadecanoic acid (25?μM, 30?min) induces a decrease in the FRET ratio signal of ERAT by 40%, indicating significantly diminished [ATP]ER?in cells that were treated with 2-Chlorohexadecanoic acid.
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