产品
编 号：F598801
分子式：C29H30F2N4O2
分子量：504.57
分子式：C29H30F2N4O2
分子量：504.57
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 847928-32-9
产品详情
生物活性：
1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects.
体内研究：
1G244 (30 mg/kg；皮下注射；每周一次；持续 3 周；NOG 雌性小鼠) 明显抑制了小鼠异种移植肿瘤模型中 MM.1S 细胞的皮下生长。Animal Model:NOD/Shi-scid IL-2Rγnull (NOG) female mice (6-7 weeks; 19-21?g) injected with MM.1?S cells
Dosage:30 mg/kg
Administration:Subcutaneous injection; once-a-week; for 3 weeks
Result:Apparently suppressed the subcutaneous growth of MM.1?S cells in murine xenograft model.
体外研究：
1G244 (0-100 μM；72 小时；Delta47、U266、KMS-5、RPMI8226 或 MM.1 S 细胞) 剂量依赖性地降低了五种多发性骨髓瘤细胞系的活细胞数。 1G244 (50 μM；0-48 小时；MM.1 S 细胞) 诱导细胞凋亡，因为检测到 caspase-3 和 PARP 的裂解形式。
1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects.
体内研究：
1G244 (30 mg/kg；皮下注射；每周一次；持续 3 周；NOG 雌性小鼠) 明显抑制了小鼠异种移植肿瘤模型中 MM.1S 细胞的皮下生长。Animal Model:NOD/Shi-scid IL-2Rγnull (NOG) female mice (6-7 weeks; 19-21?g) injected with MM.1?S cells
Dosage:30 mg/kg
Administration:Subcutaneous injection; once-a-week; for 3 weeks
Result:Apparently suppressed the subcutaneous growth of MM.1?S cells in murine xenograft model.
体外研究：
1G244 (0-100 μM；72 小时；Delta47、U266、KMS-5、RPMI8226 或 MM.1 S 细胞) 剂量依赖性地降低了五种多发性骨髓瘤细胞系的活细胞数。 1G244 (50 μM；0-48 小时；MM.1 S 细胞) 诱导细胞凋亡，因为检测到 caspase-3 和 PARP 的裂解形式。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备