产品
编 号：F598017
分子式：C8H8N4O4S3
分子量：320.37
分子式：C8H8N4O4S3
分子量：320.37
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 3368-13-6
产品详情
生物活性：
Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures.
体内研究：
Benzolamide (90 μmol/kg；腹腔注射) 降低大鼠大脑 pH 值并抑制脑电图窒息后癫痫发作。Animal Model:Male and female Wistar Han rats (11-day-old)
Dosage:90 μmol/kg
Administration:A single i.p.
Result:Induced a fast brain acidosis of a comparable magnitude.Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH.
体外研究：
Benzolamide 抑制 hCA I、hCA II、EcoCAγ 和 VchCAγ，Ki 值分别为 15 nM、9 nM、94 nM 和 78 nM。 Benzolamide 对 CAS3 (Ki=54 nM) 的选择性高于 CAS1 (Ki=2115 nM) 和 CAS2 (Ki= 410 纳米)。
Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures.
体内研究：
Benzolamide (90 μmol/kg；腹腔注射) 降低大鼠大脑 pH 值并抑制脑电图窒息后癫痫发作。Animal Model:Male and female Wistar Han rats (11-day-old)
Dosage:90 μmol/kg
Administration:A single i.p.
Result:Induced a fast brain acidosis of a comparable magnitude.Suppressed electrographic seizures after asphyxia by slowing down the recovery of brain pH.
体外研究：
Benzolamide 抑制 hCA I、hCA II、EcoCAγ 和 VchCAγ，Ki 值分别为 15 nM、9 nM、94 nM 和 78 nM。 Benzolamide 对 CAS3 (Ki=54 nM) 的选择性高于 CAS1 (Ki=2115 nM) 和 CAS2 (Ki= 410 纳米)。
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