产品
编 号：F597390
分子式：C39H46N4O3
分子量：618.81
分子式：C39H46N4O3
分子量：618.81
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1883650-95-0
产品详情
生物活性：
CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model. CDDO-3P-Im is a orally active necroptosis inhibitor that can be used for the research of ischemia/reperfusion (I/R).
体内研究：
CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies.CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.Animal Model:Seven week-old female A/J mice
Dosage:50 mg/kg, 200 mg/kg
Administration:Diet; for 16 weeks
Result:Decreased the number, the size and the severity of tumors.
体外研究：
CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM.CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC50 of 4.3 nM.
CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model. CDDO-3P-Im is a orally active necroptosis inhibitor that can be used for the research of ischemia/reperfusion (I/R).
体内研究：
CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies.CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.Animal Model:Seven week-old female A/J mice
Dosage:50 mg/kg, 200 mg/kg
Administration:Diet; for 16 weeks
Result:Decreased the number, the size and the severity of tumors.
体外研究：
CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM.CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC50 of 4.3 nM.
产品资料
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