产品
编 号：F595603
分子式：C12H21ClFN
分子量：233.75
分子式：C12H21ClFN
分子量：233.75
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1639210-25-5
产品详情
生物活性：
Fluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects.
体内研究：
Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ?25-35-induced learning impairments in mice.Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ?25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice.Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats.Animal Model:Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35
Dosage:0.1, 0.3, 1, 3, 10 mg/kg
Administration:I.p. 30 minutes before the behavioral tests
Result:Attenuated Aβ?25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit.
Fluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects.
体内研究：
Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ?25-35-induced learning impairments in mice.Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ?25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice.Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats.Animal Model:Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35
Dosage:0.1, 0.3, 1, 3, 10 mg/kg
Administration:I.p. 30 minutes before the behavioral tests
Result:Attenuated Aβ?25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit.
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