产品
编 号：F595247
分子式：C21H18N2O3
分子量：346.38
分子式：C21H18N2O3
分子量：346.38
产品类型
规格
价格
是否有货
结构图
CAS No: 1255516-86-9
产品详情
生物活性：
MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling.
体外研究：
MS-1020 (0-50 μM; 24 h) inhibits STAT92E transcriptional activity in cultured Drosophila cells.MS-1020 (0, 10, 30 , 50 μM) decreases the expression of tyrosine phosphorylated STAT3 levels and shows no changes on total STAT3 levels.MS-1020 (0, 10, 30 , 50 μM; 16 h) decreases the expression of IL-2 (100 ng/ml)-induced STAT5 phosphorylation in Nb2 cells.MS-1020 (0, 10, 30 , 50 μM; 72 h) promotes cell death in a time- and dose-dependent manner in L540 cells.MS-1020 (0, 10, 30 , 50 μM; 72 h) induces apoptosis in L540 cells.
MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling.
体外研究：
MS-1020 (0-50 μM; 24 h) inhibits STAT92E transcriptional activity in cultured Drosophila cells.MS-1020 (0, 10, 30 , 50 μM) decreases the expression of tyrosine phosphorylated STAT3 levels and shows no changes on total STAT3 levels.MS-1020 (0, 10, 30 , 50 μM; 16 h) decreases the expression of IL-2 (100 ng/ml)-induced STAT5 phosphorylation in Nb2 cells.MS-1020 (0, 10, 30 , 50 μM; 72 h) promotes cell death in a time- and dose-dependent manner in L540 cells.MS-1020 (0, 10, 30 , 50 μM; 72 h) induces apoptosis in L540 cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备